The West Indian League began operations from the home of its president, George Croasdaile, on Peckham's Lyndhurst Road. By July 1965, now with 500 members, the League set up offices at 127a Lordship Lane, East Dulwich. They moved again in September 1967, to an office in the former Holly Tree pub, Bermondsey, which had been provided for them by Southwark Council. On this last move, they faced a 900-signature petition from local people opposing their arrival in the neighbourhood, apparently under the impression that it would be a 'turned into a club with drug taking and unruly behaviour', as Southwark Trades Council reported. Relations later improved, partly through president George Croasdaile's regular tea parties.
The League ran an information bureau providing education and welfare advice, and held socials once a month. Accommodating working mothers, they also arranged a foster-mother network, for mothers to share parenting as they worked. From August 1965, concerned about the prevalence of the Ku Klux Klan in Brixton, they began patrols to 'spy out Ku Klux Klan activities'. In West Indian neighbourhoods, patrols were active after midnight, on the lookout for young men in cars, who the League suspected to be acting under the influence of the Klan. Later in their life, in 1970, Croasdaile began a scheme for black teenagers to offer community help to their neighbours, in an effort 'to improve racial harmony'.